Biological Age Test
Epigenetic clock
🧬Epiclock🧬is a biological age test that belongs to the group of epigenetic clocks, first developed by Dr. Horvath from UCLA in 2013 (1). Epigenetic clocks measure our biological age by the DNA methylation state of our epigenome, which are able to predict mortality, frailty, and the onset of some age-related diseases like Alzheimer with higher precision than telomere’s length or chronological age (2).
🧬We offer a similar clock based on the Elovl2 gene, which contributes to aging by regulating lipid metabolism. The epigenetic alterations in this gene are highly correlated with chronological age prediction and accelerated aging conditions (3-5).
🧬Alone or in combination with body composition and blood metabolic markers, this test is useful to monitor the efficiency of our programs or any other reverse-aging intervention that you try, including sleep optimization, anti-aging supplements, fasting protocols, exercise, and guided meditation (6).
References:
(1) Horvath S. DNA methylation age of human tissues and cell types. Genome Biol. 2013;14(10):R115. doi: 10.1186/gb-2013-14-10-r115. Erratum in: Genome Biol. 2015;16:96. PMID: 24138928
(2) Jylhävä J, Pedersen NL, Hägg S. Biological Age Predictors. EBioMedicine. 2017 Jul;21:29-36. PMID: 28396265
(3) Li, X., Wang, J., Wang, L. et al. Lipid metabolism dysfunction induced by age-dependent DNA methylation accelerates aging. Sig Transduct Target Ther 7, 162 (2022)
(4) Slieker, R.C., Relton, C.L., Gaunt, T.R. et al. Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception. Epigenetics & Chromatin 11, 25 (2018)
(5) Paparazzo, E.; Lagani, V.; Geracitano, S.; Citrigno, L.; Aceto, M.A.; Malvaso, A.; Bruno, F.; Passarino, G.; Montesanto, A. An ELOVL2-Based Epigenetic Clock for Forensic Age Prediction: A Systematic Review. Int. J. Mol. Sci. 2023, 24, 2254
(6) Fitzgerald KN, Hodges R, Hanes D, Stack E, Cheishvili D, Szyf M, Henkel J, Twedt MW, Giannopoulou D, Herdell J, Logan S, Bradley R. Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial. Aging (Albany NY). 2021 Apr 12; 13:9419-9432